Laboratory testing, especially secondary confirmatory testing, plays a vital role in the accuracy and reliability of drug testing processes. When initial drug screenings at the point of care yield non-negative results, it’s essential to perform further analysis to confirm these findings. Liquid chromatography-tandem-mass spectrometry provides a high level of specificity and sensitivity, making it an invaluable tool for accuracy when it comes to validating false positives caused by other compounds, such as certain antihistamines. By employing these sophisticated laboratory methods, organisations can make informed decisions, uphold fairness in testing procedures, and ensure that actions taken based on test results are justified and accurate.